Texas A&M University (TAMU) VTPB 221 Great Diseases of the World Exam 2 Practice

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Smallpox in humans is caused by which virus?

Measles virus

Herpes simplex virus

Vesicular stomatitis virus

Variola Virus

Smallpox in humans is caused by Variola virus, a member of the Orthopoxvirus genus in the Poxviridae family. This large, brick-shaped, enveloped DNA virus replicates in the cytoplasm and has historically caused the classic smallpox disease. The other viruses listed cause different illnesses—measles, herpes infections, and vesicular diseases in animals—not smallpox. So Variola virus is the agent responsible for smallpox.

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